Technology
ON-BOARD™ Overview
OncoNano’s ON-BOARD™ technology is designed to efficiently direct a wide variety of therapeutic payloads to the tumor microenvironment.
ON-BOARD™ ultra pH-sensitive polymeric micelles protect payloads from systemic exposure and target tumors by responding to tumor acidity– a well-established metabolic hallmark shared by most solid tumors regardless of tissue origin and pathology. The simplicity of the micelle approach eliminates the need for more complex surface biomarkers that may limit therapeutic utility due to expression heterogeneity.
ON-BOARD™ Features:
Micelles can be tuned to accommodate small molecules, biologics, immune active small proteins, and nucleic acids.
Payloads can be physically encapsulated or chemically bound to the micelle’s polymer core.
Encapsulation improves payload pharmacokinetics for increased tumoral exposure and tumor specific pharmacodynamic effects.
Minimizes systemic exposure and toxicity from potent payloads to improve their therapeutic index in patients.
OncoNano is actively pursuing partnerships using the ON-BOARD™ platform.