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ONM-501
A Phase 1 Dose-escalation and Expansion Study of an Intratumorally Administered Dual STING Agonist (ONM-501) Alone and in Combination with Cemiplimab
ONM-501
ONM-501
Pegsitacianine
Detection of Residual Peritoneal Metastases Following Cytoreductive Surgery Using Pegsitacianine, a pH-Sensitive Imaging Agent: Final Results from a Phase II Study
Pegsitacianine
Pegsitacianine
ONM-412
Preclinical characterization of ONM-412, an ultra-pH sensitive nanoparticle encapsulated IL-12 fusion protein
ONM-412
ONM-412
ONM-412
Encapsulation of IL-12 with an ultra pH-sensitive tumor delivery platform improves tolerability and promotes antitumor response in a preclinical model
ONM-412
ONM-412
ONM-412
Encapsulation of IL-12 with an ultra pH-sensitive nanoparticle platform improves tolerability and promotes antitumor response in mice
ONM-412
ONM-412
ON-BOARD™
Improved Tolerability and Tumor Specific Delivery of a Therapeutic Bispecific T Cell Engager Using a pH-Sensitive Nanoparticle Platform
ON-BOARD™
ON-BOARD™
ONM-501
ONM-501, a dual-activating polyvalent STING agonist, enhances tumor retention and demonstrates favorable preclinical safety profile
ONM-501
ONM-501
ON-BOARD™
A Clinically Validated pH-Sensitive Nanomedicine Platform for Encapsulating Therapeutic Bispecific T Cell Engagers for Tumor Specific Delivery and Activation
ON-BOARD™
ON-BOARD™
ONM-501
A polyvalent STING agonist, exhibits anti-tumor efficacy with increased tumor T-cell infiltration in mice and is well tolerated in rats and non-human primates
ONM-501
ONM-501
ONM-501
ONM-501 – A polyvalent STING agonist for oncology immunotherapy
ONM-501
ONM-501
ON-BOARD™
Encapsulating therapeutic antibodies for tumor specific activation and delivery using a clinically validated pH-sensitive nanoparticle platform
ON-BOARD™
ON-BOARD™
ONM-501
Prolonged activation of innate immune pathways by a polyvalent STING agonist
ONM-501
ONM-501
ON-BOARD™
Exploiting nanoscale cooperativity for precision medicine
ON-BOARD™
ON-BOARD™
Pegsitacianine
Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery
Pegsitacianine
Pegsitacianine
ON-BOARD™
PET Imaging of Occult Tumours by Temporal Integration of Tumour-acidosis Signals from pH-sensitive 64Cu-Labelled Polymers Nat BME, Huang, 2020 314-324
ON-BOARD™
ON-BOARD™
Pegsitacianine
Image Guided Surgery for Tumor Agnostic Detection of Solid Tumors Using the pH Activated Micellar Imaging Agent ONM-100
Pegsitacianine
Pegsitacianine
ON-BOARD™
Transistor-like Ultra-pH-Sensitive Polymeric Nanoparticles
ON-BOARD™
ON-BOARD™
Pegsitacianine
Investigation of endosome and lysosome biology by ultra pH-sensitive nanoprobes
Pegsitacianine
Pegsitacianine
Pegsitacianine
A transistor-like pH nanoprobe for tumour detection and image-guided surgery
Pegsitacianine
Pegsitacianine
ON-BOARD™
Digitization of endocytic pH by hybrid ultra-pH-sensitive nanoprobes at single-organelle resolution
ON-BOARD™
ON-BOARD™
Pegsitacianine
Molecular basis of cooperativity in pH-triggered supramolecular self-assembly
Pegsitacianine
Pegsitacianine
Pegsitacianine
Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions JACS, MA, 2014
Pegsitacianine
Pegsitacianine