A Phase 1 Dose-escalation and Expansion Study of an Intratumorally Administered Dual STING Agonist (ONM-501) Alone and in Combination with Cemiplimab

Detection of Residual Peritoneal Metastases Following Cytoreductive Surgery Using Pegsitacianine, a pH-Sensitive Imaging Agent: Final Results from a Phase II Study

Preclinical characterization of ONM-412, an ultra-pH sensitive nanoparticle encapsulated IL-12 fusion protein

Encapsulation of IL-12 with an ultra pH-sensitive tumor delivery platform improves tolerability and promotes antitumor response in a preclinical model

Encapsulation of IL-12 with an ultra pH-sensitive nanoparticle platform improves tolerability and promotes antitumor response in mice

Improved Tolerability and Tumor Specific Delivery of a Therapeutic Bispecific T Cell Engager Using a pH-Sensitive Nanoparticle Platform

ONM-501, a dual-activating polyvalent STING agonist, enhances tumor retention and demonstrates favorable preclinical safety profile

A Clinically Validated pH-Sensitive Nanomedicine Platform for Encapsulating Therapeutic Bispecific T Cell Engagers for Tumor Specific Delivery and Activation

A polyvalent STING agonist, exhibits anti-tumor efficacy with increased tumor T-cell infiltration in mice and is well tolerated in rats and non-human primates

ONM-501 – A polyvalent STING agonist for oncology immunotherapy

Encapsulating therapeutic antibodies for tumor specific activation and delivery using a clinically validated pH-sensitive nanoparticle platform

Prolonged activation of innate immune pathways by a polyvalent STING agonist

Exploiting nanoscale cooperativity for precision medicine

Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery

PET Imaging of Occult Tumours by Temporal Integration of Tumour-acidosis Signals from pH-sensitive 64Cu-Labelled Polymers Nat BME, Huang, 2020 314-324

Image Guided Surgery for Tumor Agnostic Detection of Solid Tumors Using the pH Activated Micellar Imaging Agent ONM-100

Transistor-like Ultra-pH-Sensitive Polymeric Nanoparticles

Investigation of endosome and lysosome biology by ultra pH-sensitive nanoprobes

A transistor-like pH nanoprobe for tumour detection and image-guided surgery

Digitization of endocytic pH by hybrid ultra-pH-sensitive nanoprobes at single-organelle resolution