Dr. Niederhuber is currently Adjunct Professor of Surgery and Oncology of the Johns Hopkins University School of Medicine and Deputy Director of the Johns Hopkins Clinical Research Network. He retired in April 2019 from his position as Executive Vice President Inova Health System, Fairfax, Virginia where he served (2010-2019) as the Chief Executive Officer and founder of the Inova Translational Medicine Institute, a not-for-profit genomics research institute. Dr. Niederhuber is the former Director of the National Cancer Institute (NCI), of the National Institutes of Health having been appointed to that position in 2006 by President Bush. Before assuming the NCI directorship, he chaired the National Cancer Advisory Board.
Dr. Niederhuber has held a number of academic leadership positions including as Director of the University of Wisconsin Comprehensive Cancer Center and professor of surgery and oncology (member of the McArdle Laboratory) at the University of Wisconsin School of Medicine from 1997 to 2005. He chaired the Department of Surgery at Stanford University School of Medicine from 1991 to 1997 and held professorships at the Johns Hopkins University School of Medicine from 1987 to 1991 and at the University of Michigan from 1973 to 1987 where he also served as Associate Dean for Research and Associate Dean Clinical Affairs. Dr. Niederhuber is a member of the National Academy of Medicine.